The service has target turnaround times for investigative processes. The majority of cases will be dealt within the target times but in some situations it may prove impossible to meet these by reason of technical or complicated diagnostic pathways.
Bristol Haemato-Oncology Diagnostic Service Reporting Times
| Tissue | Target Reporting Time3 |
|---|---|
| Bone Marrow1 | 7 days |
| Tissue2 | 10 days |
1. Includes haematological morphology, immunophenotyping and trephine histopathology
2. Includes lymph node morphology and immunohistochemistry
3. Where supplementary tests are required the target reporting times are as detailed below
Haematological morphology
| Investigation | Target Reporting Time |
|---|---|
| Peripheral blood morphology | 24 hours (working week) |
| Bone marrow morphology | 72 hours (working week) |
Immunophenotyping
| Investigation Target | Target Reporting Time |
|---|---|
| Haematological malignancies - urgent | within 4 hours of receipt |
| Haematological malignancies - routine | 1 working day |
| PNH Screen | 1 working day |
Histopathology
| Tissue/process | Target Reporting Time |
|---|---|
| Lymph node morphology | 3 working days |
| Lymph node immunohistochemistry | 4 working days |
| Bone marrow trephine | 4 working days |
| Bone marrow immunohistochemistry | 7 working days |
Cytogenetics
| Investigation | Target Reporting Time |
|---|---|
| Urgent karyotype e.g. AML, ALL, CML | 7 calendar days |
| Routine karyotype e.g. MDS, MPN | 21 calendar days |
| Urgent (Priority 1) FISH e.g. BCR/ABL1, PML/RARA | 3 working days |
| Urgent (Priority 2) FISH e.g. CLL, FFPE | 14 calendar days |
| Routine (Priority 3) FISH e.g. Myeloma | 21 calendar days |
Molecular Pathology
| Investigation | Target Reporting Time |
|---|---|
| Quantitative BCR-ABL1 | 3 working days |
| Quantitative BCR-ABL1 monitoring in CML and ALL | 14 calendar days |
| ABL1 kinase domain mutation testing | 28 working days |
| JAK2 (V617F) mutation analysis | 14 calendar days |
| CALR (exon 9) mutation analysis | 14 calendar days |
| JAK2 (exon 12) mutation analysis | 28 working days |
| MPL (exon 10) mutation analysis | 28 working days |
| KIT (exon 8 and 17) mutation analysis | 14 calendar days |
| IG/TCR clonality assessment | 14 calendar days |
| IGVH mutation and gene usage in ALL | 14 calendar days |
| BRAF (V600E) mutation testing | 14 calendar days |