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Trials Recruiting

MASTER Trial
Male synthetic sling versus Artificial urinary Sphincter Trial for men with urodynamic stress incontinence after prostate surgery: Evaluation by Randomised controlled trial.

The purpose of the MASTER research study is to compare two different types of surgery for men with urine leakage (urinary incontinence) after prostate surgery, in order to identify the most effective operation. This will be done by dividing men who suffer from urinary incontinence between two different types of surgery that are used to treat this problem. The improvement in urinary incontinence will be used to compare the success of the surgeries. The results from this study will show which operation is the most effective operation in treating urinary incontinence and will help men who suffer from the problem in the future.

Further information is available through the Research Nurses at the BUI or by contacting master@abdn.ac.uk or telephone 01224 438096.

PrEvENT: Prostate Cancer Evidence of Exercise and Nutrition Trial
Previous research has suggested that specific foods and being physically active may provide particular benefits for men with prostate cancer. The aim of this study is to look at men who have been diagnosed with localised prostate cancer and are waiting for surgical treatment (radical prostatectomy) and see whether certain foods and levels of physical activity slows down the growth of prostate cancer or reduces the risk of the cancer returning after surgery.

POUT: PeriOperative chemotherapy or sUrveillance in upper Tract urothelial cancer
The POUT study is investigating whether people with upper tract urothelial cancer (cancer that has grown into the wall of the ureter, the part of the kidney called the renal pelvis, or into the surrounding lymph glands) will benefit from further treatment after surgery. There is evidence that chemotherapy reduces the risk of cancer coming back after surgery for breast and bowel cancer. POUT is the first study that could establish whether chemotherapy works for upper tract urothelial cancer.

The POUT study has been set up to try to find out whether chemotherapy should be given within a few months after surgery to help to prevent the cancer from returning, or whether close surveillance following surgery is the best approach.

PREVENTT (Preoperative intravenous iron to treat anaemia in major surgery)
The BUI is involved in a research study called PREVENTT. This national study is to see whether iron therapy can reduce the need for blood transfusions in patients who have surgery. The study is funded by public funds and it is organised with University College London. Further information is avilable at http://preventt.lshtm.ac.uk/

IMPAQTS
This is a study designed to explore bladder and bowel issues associated with progressive Multiple Sclerosis.

Bladder and bowel symptoms are common among men and women with primary and secondary progressive MS. Leakage or urine (UI) and bowel control problems (faecal incontinence FI) can occur on their own or together but little is known about how many people do experience these symptoms and to what extent. The aim of this project therefore is to accurately find out how many people with MS experience UI and/or FI and to explore the impact of these symptoms on quality of life and sexual function. It is hoped that the outcome of this research will help healthcare practitioners to better understand the importance of these issues for those who suffer with them.

Patient’s involvement will be in the form of filling in a series of questionnaires. If you are over 18 years old with a diagnosis of progressive MS and experience any difficulties controlling your bladder and/or bowels, we would be really interested in hearing from you.

This MS Society-funded research study will be led by Dr Nikki Cotterill (Research Fellow) and conducted by Mrs Carole Copestake (Research Nurse).

If you would like to find out more about this study and would like to receive a participant information sheet, please contact Carole Copestake at carole.copestake@nbt.nhs.uk or telephone leaving your name and number on 0117 4148247 and we will return your call. Please note that enquiring about participation does not commit you in any way. 

RADICALS: Radiotherapy Timing Randomisation (RADICALS-RT). Clinical trial of treatment after surgery for prostate cancer
Radiotherapy is often used in combination with surgery in other types of cancer. This is because it is often better for patients than using surgery alone.  In prostate cancer, surgery alone is a standard approach, and we want to know if adding radiotherapy would be better.

This trial is looking at when should radiotherapy be used after surgery.  Patients who get involved in this study will be randmoised to one of these two approaches:

  • Early radiotherapy (3 to 6 months after surgery)
  • Deferred radiotherapy (only if your PSA (Prostate Specific Antigen) level starts to rise)

Hormone Duration Randomisation (RADICALS-HD): Clinical trial of treatment after surgery for prostate cancer
This trial is open for men who have had their prostate removed and are due to have radiotherapy. The aim of the study is to find out which is the best way to use hormone treatment.

When radiotherapy is used after surgery for prostate cancer, it can be given with or without hormone treatment. RADICALS will compare these approaches.  Patients in the study will be allocated to one of these three treatments:

  • either radiotherapy alone
  • or radiotherapy plus 6 months hormone treatment
  • or radiotherapy plus 2 years hormone treatment

UNBLOCS: Urinary OBstruction relieved by Laser Or Conventional Surgery
As men get older it is common for their prostate gland to get bigger, this is known as benign prostatic enlargement (BPE). This can result in difficulties with passing urine or other bothersome lower urinary tract symptoms. When this happens it is known as benign prostatic obstruction (BPO). Surgery is often used to reduce the size of the prostate to relieve the symptoms of BPO.

The standard operation in use in the National Health Service (NHS) is called Trans-Urethral Resection of the Prostate (TURP). Laser treatments have also been used in the NHS but are less common and there is currently not enough research to know if one type of operation is better than another, or if they have similar outcomes. This trial will be comparing TURP with a laser operation called thulium laser transurethral vaporesection of the prostate (ThuVARP).

Patients may be invited to take part in this study if they have been diagnosed as having BPO that requires surgery. The aim of this trial is to find out which of the operations gives the better results, is safer and is more cost-effective (for patients and the NHS), or whether they both have similar outcomes.

The ThuVARP laser is easier for surgeons to use, and this study will help to establish how it compares with TURP for men and the NHS.

UPSTREAM: Urodynamicsfor Prostate Surgery Trial; Randomised Evaluation of Assessment Methods
Effectiveness of invasive urodynamics in men who have persistent bladder outlet obstruction and are considering surgery. The UPSTREAM trial will compare two assessment pathways for men. Pressure-flow studies v flow rates

TISU: Therapeutic Interventions for Stones of the Ureter
Urinary stone disease is very common and painful.  If the stones do not pass naturally or interim treatments have not worked then stone removal is required. The two ways this is done:

  • Extracorporeal Shockwave Lithotripsy (ESWL), which is a shockwave treatment applied from the outside of the body, and
  • Ureteroscopic stone treatment, a telescopic procedure to remove the stone.

Both procedures are used in the NHS to remove stones and the aim of the study is to find out which treatment is better

If you have any questions or would like any more information telephone: +44 (0)1224 438189, email: tisu@abdn.ac.uk
or visit www.charttrials.abdn.ac.uk/tisu. Local contact details: Principal Investigator: Joe Philip

MeNiMS Study: Melatonin for Nocturia in MS
A randomized double blind placebo controlled access cross over trial of Melatonin for the treatment of nocturia in adults with multiple sclerosis (MS).

In MS urinary symptoms are common, including nocturia, along with sleep disturbance. Melatonin is a natural occurring hormone in humans which regulates the natural pattern of physical and behavioural processes (known as circadian cycles). Melatonin levels increase when it is dark and seem to help sleep. Nocturia may be a sign of impaired circadian regulation. The aim of this study is to find out whether taking melatonin as a sustained-release table could improve nocturia and aid quality of life in patients with MS.

Patients can be part of the trial if they have multiple sclerosis and have a least 1 episode of nocturia every night.