Orthopaedics & Trauma Research Past Projects

The team are building a nationwide and global reputation for outstanding Orthopaedic & Trauma clincial research

PROFHER

 PROximal Fractures of the Humerus: Evaluation by Randomisation
This study looked at patients who had broken (fractured) the top end of their upper arm bone (humerus). These fractures are common in older people and in less serious cases, they are treated by supporting the arm in a sling to help the bone to heal. In about half of these fractures it is more serious and the patient requires surgery. However, for the majority of serious fractures surgeons are not sure whether an operation is better than supporting the arm in a sling and leaving the bone to heal. Therefore this study wanted to know which of these two treatments (sling or operation) was better for these more serious fractures.

London Clavicle

This study looked at patients who had broken (fractured) their collarbone. Some fractures heal well but other fractures (displaced) require surgery as they may not heal by themselves. At this time no proper comparison had been done to scientifically prove whether surgery or non-operative treatment was better for these displaced fractures.  The purpose of this study was to see if surgery improves healing and function compared to non-surgical treatment.

PATH-2

Platelet Rich Plasma in Achilles Tendon Healing
This study looked at patients who had ruptured their Achilles tendon (this connects your calf muscles to your heel bone). Standard treatment for these patients not requiring an operation is to place the ankle into a cast, splint or boot and allow the body to heal itself naturally. A new treatment has been developed using a sample of the patient’s blood and extracting the “platelet rich plasma” from it. This plasma contains special growth and regeneration factors that can be injected into the Achilles tendon. This method has been shown to accelerate healing in a small group of patients. PATH-2 looked at a larger group of patients to see whether this was an effective treatment.

FixDT

UK Fixation of Distal Tibia Fractures
This study looked at investigating two different ways of fixing a broken shin bone (of the leg). For patients who have broken the lower part of their shin bone (distal tibia) there are several treatment options. Sometimes the broken bone can be held in a plaster cast. However, the majority of breaks require surgery. During surgery the bone is commonly fixed with a metal device which is under the skin. The device can sit inside the hollow part of the bone (a “nail”) or can sit on the surface of the bone (a “plate”). This study compared plates versus nails with regards to the time required for the bone to heal, ankle function and quality of life.

INSITE

Intramedullary Nail versus sliding hip Screw Inter-Trochanteric Evaluation
This study looked at patients who had broken their hip and sustained a ‘Pertrochanteric fracture’. Pertrochanteric fractures are commonly treated with an operation where they “internally fix” the fracture. The two common methods of internal fixation are Gamma intramedullary nails and sliding hip screws. It is unknown whether nails have better outcomes than screws. This study compared these two types of operation.

COTS

This study looked at patients that had an isolated ulnar shaft fracture (a forearm fracture where only one of the forearm bones is broken). There are currently two treatment methods used across North America and Europe. The bones can be manipulated (closed reduction as the skin is not opened) to re-establish a normal position of the bones, followed by the application of a cast for 6 weeks. Another method is surgery; opening the skin and replacing the bone pieces under direct vision (open reduction) and maintains this with plate and screws. Research over the last 15 years has found inconclusive evidence to show which treatment works best. Therefore this study wanted to determine if surgery using a plate and screws will improve healing in an ulnar shaft fracture versus non-surgical treatment.

WOLLF

Wound management of Open Lower Limb Fractures
This study compared two different types of wound dressings for patients who had an open (exposed through the skin) fracture of the leg. Once the patient had surgery to clean the bones and fix them back into place their wound was covered in a sterile dressing. The research compared ‘standard dressing’ (sterile gauze with a traditional bandage) to ‘suction dressing’ (which also covers the wound with a sterile dressing but it is attached to a machine which gently ‘sucks’ on the dressing to remove any build-up of fluid).

Furlong Evolution® Hip Trial

This is a commercial study reviewing progress of patients who have undergone total hip replacement surgery using the Furlong short stem implant. The potential benefit for using a short stem implant is that it aids early mobilisations and preserves the femoral bone should further surgery be required.

WHISTL:ER

Follow up of hip arthroplasty Long term: Effect on Revision
This is a study funded by the National Institute for Health Research the effectiveness of hip arthroplasty surveillance (long term follow-up). The primary objective is to investigate if there is a difference in the health related quality of life after hip revision surgery between patients diagnosed through routine surveillance and those who have not had any form of long term follow up.