Cytogenetics Oncology at Bristol Genetics Laboratory

Bristol Genetics Laboratory (BGL) offers a comprehensive service for cytogenetic testing of oncology samples; primarily for haematological malignancy but also for a range of solid tumour and other referrals.


What is Cytogenetics?


Cytogenetics is the study of the structure and function of chromosomes. We analyse chromosomes by G-banded metaphase karyotyping, comparing the unique banding pattern of each chromosome pair. Changes in the number or structure of chromosomes can lead to serious problems, such as cancer. A normal cytogenetic result does not exclude the presence of an undetected or cryptic disease related clone.


Chromosome analysis is frequently supplemented by:

  • FISH (Fluorescence in situ Hybridisation) 
  • Molecular pathology investigations


When do we analyse chromosomes?


  • Diagnosis
  • for new patients
  • classification of the disease 
  • Prognosis 
  • diseases where specific disease related chromosome rearrangements are known 
  • for risk stratification
  • Monitoring
  • follow-up studies for cases of relapse
  • where previous cytogenetic abnormalities have been documented
  • transplant and treatment success
  • Patients in clinical trials


analyse chromosomes


For a full list of disease tests, please see the A-Z of Services


Please also see the Sample Requirements


Last updated: 12th December 2016


Test Information

Test information

Includes details of sample types, volumes, special precautions, turnaround times & reference ranges.