Solid Tumour Testing

The Bristol Genetics Laboratory offers an expanding repertoire of molecular and cytogenetic tests for a range of solid tumour types, useful for confirming diagnosis, assessing prognosis and for guiding therapeutic decisions. This stratified or personalised medicine approach is important in the treatment and management of patients with solid tumours. Our laboratory offers state-of-the-art clinical molecular testing for a range of clinically actionable genes in a variety of tumour types.

Lung Cancer

  •  Lung cancer NGS panel (EGFR, BRAF, PIK3CA, KRAS and ERBB2)
  •  Lung cancer RNA fusion panel (ALK, RET, ROS1)
  •  ALK FISH analysis
  •  EGFR circulating tumour DNA (ctDNA) for exon 19 deletions, p.(Leu858Arg) and p.(Thr790Met)


  •  Melanoma gene panel (BRAF, KIT, NRAS, GNA11 and GNAQ)
  •  BRAF codon 600 mutation analysis

Colorectal Cancer

  •  Colorectal gene panel (KRAS, NRAS and BRAF)
  •  MSI analysis
  •  BRAF codon 600 mutation analysis
  •  MLH1 promoter hypermethylation analysis


  • GIST gene panel (KIT, PDGFRA, BRAF, KRAS and NRAS)

Brain Tumours

  •  MGMT promoter methylation analysis
  •  1p and 19q co-deletion analysis
  •  IDH1 codon 132 and IDH2 codon 172 sequence analysis
  •  H3F3A codon 28 and 35 and HIST1H3B codon 28 sequence analysis
  •  TERT promoter analysis
  •  BRAF codon 600 mutation analysis
  •  BRAF fusion RT-PCR and FISH analysis
  •  EGFR amplification FISH analysis
  •  MYC FISH analysis
  •  MYCN FISH analysis

Tumour agnostic

  •  NTRK1/2/3 RNA fusion panel

For further information regarding any of these tests please see the Test List for Oncology Genomics Services or contact the laboratoryFor requesting please use the Molecular Pathology Request Form download 

 or Neuropathology Request Form 

  as appropriate.

Last Updated 11th April 2021