Opioids
What is an opioid?
Opioid refers to morphine and ‘morphine type’ medications. They have been used for many years to treat pain.
Examples of mild opioids include codeine, dihydrocodeine, and tramadol. Sometimes these are combined with paracetamol as research has shown they work better together. They include:
- Codeine and paracetamol (co-codamol).
- Dihydrocodeine and paracetamol (co-dydramol).
- Tramadol and paracetamol (Tramacet).
Stronger opioid drugs include morphine, oxycodone, buprenorphine, fentanyl, diamorphine, alfentanil, and methadone. Opioid medicines come in many forms including tablets, capsules, liquids, skin patches, and injections.
What are opioids used for?
Opioids provide pain relief by mimicking the body’s natural pain relief (endorphins). They are used when the pain is moderate to severe after an operation or accident. They are also used at different stages of illness.
Opioid medicines can help manage some, but not all types of pain, and they will be prescribed by your medical team in hospital or your GP if it is felt they are the best treatment for your pain.
What are the benefits of taking opioids?
Opioid medicines can help manage pain when other medicines are not suitable, or do not provide enough pain relief. They may help reduce your suffering or distress, and may improve your ability to function physically and socially. They may also allow you to sleep and eat better.
What are the usual doses of opioids and how should I take them?
The correct dose of any medicine is the lowest dose that produces a noticeable benefit. It is unusual to get complete relief of pain from opioids.
However, it is important to find the most effective dose for you to reduce your pain. The amount needed to control pain varies between people. There is no standard dose of opioid.
Pain is a very personal experience
It is important to understand that the medication/opioids prescribed for your pain may not completely stop your pain – this is normal. The aim of these opioids is to make pain manageable, so you are able to carry out normal daily activities.
You will usually start with a low dose and gradually build up until you find the dose that helps with your pain. The doses can be changed, and other pain medicines can be trialed so your pain is kept under control. Your doctor may try more than one kind of opioid if one type is not right for you.
It is important to control background pain, which is constant and continuous, so you will take a dose at a regular time each day to prevent the pain building up again.
You may have additional medicine for breakthrough pain, which is a sudden, intense pain in addition to the background pain. This will be a short acting preparation (“immediate release”). This acts quickly but usually wears off within a few hours.
It is important to take your pain medicines as they are prescribed.
What if I forget or miss a dose?
If it is almost time for your next dose, skip the missed dose and take your medication as normal (you must leave the prescribed number of hours between doses).
Never take two doses together.
What if the opioids do not control my pain?
If you are using opioids but are still in pain, the opioids are not effective for your pain control and should be stopped by your doctor. Please seek medical advice on weaning opioids if they are not helping to manage your pain- they should not just be stopped.
- Morphine/morphine equivalent medication doses that are 120mg or above per day (24 hour period) greatly increase the risk of harm caused to your body. Research shows there is no increased benefit to pain control above this 120mg total dose.
If you have significant pain after surgery and are sent home with an opioid prescription, it should be limited to a small amount. If you do take opioids, take them only for a day or two, three days at most. Your pain will improve significantly within a few days whether you take opioids or not.
Can I take this medicine long-term?
While opioids can have a positive effect for some people living with long-term pain, research shows that opioids have little to no benefit for nerve pain.
Taking opioids long term can have serious consequences when they are not providing enough benefit or are being taken not as prescribed. It is important to consider the risks and benefits of continued opioid therapy with your prescriber on a regular basis.
Recent medical research suggests that the risks to your health increase significantly when taking prescribed opioids at high doses for a long period of time. Health risks include accidental overdose or even death.
What are the possible side effects of opioids?
When you first start taking opioids you can experience some side effects, which usually stop after a few days. These include:
- Feeling dizzy.
- Feeling sick (nausea).
- Being sick (vomiting).
- Feeling sleepy.
- Feeling confused.
- Feeling constipated.
Please let your doctors know if you experience any of the above. Some side effects can be helped with other medication or alternative pain medication may need to be changed.
It is important to take pain medicine for the shortest possible time. If you want to try reducing your dose, you should discuss this with your doctor and bring the dose down slowly.
Many people find they can reduce their opioid dose without the pain increasing. As fewer side effects are experienced, quality and enjoyment of life can improve. All of this contributes to greater physical fitness.
What about addiction to pain killers?
Following surgery, many patients go home with an opioid pain medicine prescription, this can sometimes trigger addiction.
It is strongly recommended to only take opioids for the shortest possible length of time. Everyone prescribed any pain medication should have them reviewed by their prescriber at regular intervals.
Remember:
- Opioid medicines should be used as little as possible, if at all, after surgery.
- Nobody should need to take them for more than a week after an operation.
- Addiction can develop after taking just a few of them.
People who are addicted to pain medicine can:
- Feel out of control about how much medicine they take or how often they take it.
- Crave the drug.
- Continue to take the drug even when it has a negative effect on their day-to-day life, physical and/or mental health.
If you have been taking opioid pain medicine for more than a week, your body may have become used to the opioid medicine and you may experience symptoms of withdrawal (sweating, stomach cramps, diarrhoea, aching muscles) and the return of your pain if you:
- Stop taking it too suddenly.
- Lower the dose too quickly.
- Run out of medicine.
You should not suddenly stop taking your opioid medicine but get advice from your doctor who will help you reduce the dose gradually and safely.
Is there anything else my prescriber needs to know?
- If you are allergic to any medications.
- If you are taking any other medication, including over the counter or herbal medication (sometimes different medications can interact with each other).
- If you are pregnant or breastfeeding, or if you are planning to become pregnant in the near future.
- If you have kidney and/or liver problems.
- If you have or have previously had a history of excessive alcohol use, recreational drug use, or addiction to prescribed or over-the-counter medication.
- If you have a condition called obstructive sleep apnoea - it may not be safe to take opioids with this condition.
It is important that you read the drug information leaflet provided with your medication on discharge. This includes more advice on driving and alcohol use along with your medicines.
Can I drink alcohol?
Taking alcohol and opioids together will cause sleepiness and reduce your ability to concentrate. When you first start taking opioids or when your dose is increased you should be more careful. When you are on a steady dose of opioid, you should be able to drink safe and modest amounts of alcohol without getting any extra unusual effects.
When you are taking opioids, you should not drink alcohol if you are going to drive or operate machinery.
Can I continue to drive?
UK law allows you to drive if you are taking opioid medicines. However, you are responsible for making sure you are safe to drive.
Because opioid medicines can make you feel sleepy, you should not drive or operate machinery until you see how it affects you. Your reactions and alertness will be affected. You should only consider driving regularly if you are confident that your concentration is not impaired. You should not drive if your dose has changed or if you feel unsafe. You do not have to inform the DVLA that you are starting an opioid. However, there may be other information about your illness that the DVLA needs to know.
Chronic/long term pain
If you have a history of chronic/long term pain and you are taking pain medicines for this at home before coming into hospital, your analgesia/pain relief will be discussed with your doctors/anaesthetist, and/or (if required) the acute pain team.
How do I store opioids at home?
It is important that only you take the opioids prescribed for your pain.
Opioid medicines should be kept in their original containers and clearly labelled. They should be stored as the information leaflet given with the medication suggests, usually at room temperature in a dry place.
As with all medicines they should be stored safely out of the reach and sight of children.
What should I do with unused opioid medicines?
- Return them to the pharmacist/pharmacy for safe disposal.
- Do not share these medications with anyone, they are prescribed for you only.
- Do not flush them down the toilet or throw them away.
Important final message
- Everyone prescribed any pain relief medicines should have them reviewed by their prescriber at regular intervals.
- Ideally pain relief medicines should be weaned and stopped safely as soon as able.
- If this does not happen ask your medical team in hospital, or your GP.
© North Bristol NHS Trust. This edition published October 2024. Review due October 2027. NBT003158.
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