Endovenous interventions are keyhole operations for varicose veins that are carried out from within the vein itself. Varicose veins are enlarged veins close to the surface of the skin. They are connected to the bigger deeper veins in the leg, known as deep veins. Because of this, operations to close the varicose veins can increase the chance of a blood clot forming in the deep veins. A blood clot in the deep veins (also known as a ‘deep vein thrombosis’ [DVT]), happens in around 1 in 59 people after endovenous operations. A clot in the leg can cause swelling, pain and other problems. If a clot in the leg breaks off and travels to the lungs (called a ‘pulmonary embolism’ [PE]), it may be life threatening.
There is a national drive to reduce blood clots by identifying those most at risk and treating them with medicines that reduce the blood’s tendency to form clots. These medicines are generally very safe but can rarely cause bleeding for example in the bowel and brain. In other short duration procedures, where people can go home on the same day, medicines to reduce blood clots are not prescribed, as developing a blood clot is so rare.
Varicose vein procedures, however, carry a slightly higher risk of blood clot formation, and we are currently unsure if these clot reducing medicines are beneficial in preventing blood clots in patients undergoing these procedures. Elastic stockings or dressings that squeeze the leg and improve the blood flow through the veins are also applied after the varicose vein procedure which helps to reduce the risk of blood clots.
The purpose of this study is to investigate if it is worthwhile prescribing anticoagulants to reduce blood clots after varicose vein procedures. People enrolled in the study will undergo an assessment to make sure that they don’t have the most important risk factors for clots. Those at high risk would not be included in the study. Some participants will receive elastic stockings or dressings alone, while other participants will receive this plus anticoagulation. A computer will decide at random the treatment you will receive.
Project Details
PI: Jude Day
Planned End date: 31/08/2026
Local Ref: 5468