|Tests to request in primary screen
|Arthralgia or arthritis
|Rheumatoid factor, Antinuclear Antibody (ANA)
|The laboratory will instigate more specific tests if indicated by the screen. A measure of the acute phase response may also be helpful.
|If ACA negative and clinical suspicion high worth checking for lupus anticoagulant. If ACA positive result needs to be confirmed 12 weeks later.
|The laboratory will confirm positive results by anti-endomysium and check for IgA deficiency as required.
|Allergen Specific IgE (formerly ‘RAST’)
|History is paramount in making the diagnosis. The test helps only to confirm the diagnosis.
|Autoimmune thyroid disease
|TSH (to assess dysfunction)
|Anti TPO helpful in the context of subclinical hypothyroidism i.e. when TSH 5-10mU/L.
|Serum Electrophoresis, Urine for Bence Jones protein
|Need to check both serum and urine. Immunofixation will be performed if indicated by screen.
|History is paramount. Please discuss with laboratory to direct testing.
|Persistent raised plasma viscosity
|Immunoglobulins, autoimmune profile, liver function tests
|Abnormal liver function/jaundice
|Autoimmune liver screen (includes ANA, anti-smooth muscle, anti-mitochondria, anti-LKM)
|Immunoglobulins may provide additional supporting information.
Contact Immunology & Immunogenetics
Head of Department
Dr Adrian Heaps
Telephone: 0117 4148473
Dr Sarah Johnston
Telephone: 0117 4148370
Telephone: 0117 4148393
Normal Laboratory Hours
Monday - Friday 8am - 5pm