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Amino Acids CSF

Container: Universal (white top)

Sample type: CSF

Test name: Amino Acids CSF a.k.a. CSF glycine, serine, threonine, alanine

Condition / Indication: Suspected NKH (non-ketotic hyperglycinaemia) or disorders of serine biosynthesis; investigation of neonatal seizures.

Special precautions & notes: Please send a paired sample for plasma amino acids for interpretation and calculation of CSF:plasma ratios

Reference range: Normal CSF:Plasma glycine ratio <0.04. See document below for age-related reference ranges for CSF glycine, serine, threonine, alanine provided below.

Container: Universal (white top)

Ideal volume (mL): 1 mL

Referred outside NBT for analysis? No

Discipline: Clinical Biochemistry

Section: Metabolic Biochemistry

Turnaround time: 14 days

www.nbt.nhs.uk/metabolic

Method:

Ion-exchange chromatography (Biochrom)