Sample type: CSF
Test name: Amino Acids CSF a.k.a. CSF glycine, serine, threonine, alanine
Condition / Indication: Suspected NKH (non-ketotic hyperglycinaemia) or disorders of serine biosynthesis; investigation of neonatal seizures.
Special precautions & notes: Please send a paired sample for plasma amino acids for interpretation and calculation of CSF:plasma ratios
Reference range: Normal CSF:Plasma glycine ratio <0.04. See document below for age-related reference ranges for CSF glycine, serine, threonine, alanine provided below.
Container: Universal (white top)
Ideal volume (mL): 1 mL
Referred outside NBT for analysis? No
Discipline: Clinical Biochemistry
Section: Metabolic Biochemistry
Turnaround time: 14 days
Method:
Ion-exchange chromatography (Biochrom)