Thiopurine Metabolites

Container: EDTA (Lavender top)

Sample type: Whole Blood

Test name: Thiopurine Metabolites a.k.a. 6-MMPN, 6-TGN, crohns monitoring

Condition / Indication: Therapeutic Drug Monitoring

Special precautions & notes: Please provide details of current thiopurine drug regime and patient diagnosis on the request form. We suggest a sample for therapeutic drug monitoring is timed at 4-6 weeks from the start of treatment or a change in dose. Request currently only accepted fron consultant gastroenterologists.

Reference range: 235 – 450 pmol 6TGN/8x108 cells = Maximum drug efficacy in inflammatory bowel disease; MEMP:TGN ratio of >11 = Associated with an increased risk of poor response to therapy.

Container: EDTA (Lavender top)

Ideal volume (mL): 4 mL

Referred outside NBT for analysis? Yes

Discipline: Clinical Biochemistry

Turnaround time: 21 days

Referral location: Purine Research Laboratory, St Thomas' Hospital, Synnovis, North Wing - 4th Floor, Westminster Bridge Road, London, SE1 7EH