Dementia Current Research

A drug trial focusing on those with pre-clinical Alzheimer’s Disease who show evidence of elevated or intermediate amyloid levels. Participants will go through screening procedures that may assess amyloid level, and then take part in a series of assessments over 4 years to track progressions while receiving drug infusions.

Project Details

PI: Dr Elizabeth Coulthard

Planned End Date: 01 Dec 2023 (recruitment end)

Local Ref: 4895

An observational study proposing to understand more of the nature, severity and frequency of sleep disturbances that are associated with real-world cognitive decline and to explore relationships between sleep and cognitive change.

Project Details

PI: Dr Elizabeth Coulthard

Planned End Date: Jan 2023 (recruitment end)

Local Ref: 4930

Our overarching goal is to refine the treatment of dementia-related sleep and memory impairment. This work will focus on both AD and LBD, together with their prodromal stages of Mild Cognitive Impairment (MCI). The RESTED Programme will invite healthy controls, alongside participants with AD, LBD and DRD to undergo a combination of sleep monitoring at home and specific tests of cognition

Project Details

PI: Dr Elizabeth Coulthard

Planned End Date: Jan 2023 (recruitment end)

Local Ref: 5123

COmBining memantine and cholinesterase inhibitors in Lewy body dementia Treatment trial

The COBALT Trial aims to find out if adding Memantine to AChEI treatment improves overall health and functioning for people with Lewy Body Dementia (DLB) or Parkinson's Disease Dementia (PDD).
A 150 patients with DLB and 150 patients with PDD, from across the UK will  take part in this trial. Participation will consist of a few visits over 52 weeks to the site for cognitive assessments, telephone follow ups and monitored use of either the placebo or Memantine. 

PI Dr Elizabeth Coulthard

Recruitment end date:01 April 2025

Local Ref: R&D 5195

Our research group and others have found links between Alzheimer’s and gum disease. Gum disease occurs when certain bacteria thrive under the gum line causing inflammation and bleeding. There is good evidence these bacteria pass into the bloodstream and speed up, or cause development of other diseases (such as diabetes and heart disease). This study monitors Alzheimer’s patients treated for gum disease for 12 months to see if this also slows their rate of memory loss. We're looking for 50 participants. 

PI: Dr Elizabeth Coulthard

Planned end Date: May 2025

Local Ref: R&D 5319

Enroll-HD is a prospective observational multicentre multi-national cohort study to be conducted in multiple native languages. Study visits will take place yearly and may occur at the time of the participant’s routine clinical care visit, where possible. The goal of Enroll-HD is to build a large and rich database of clinical information and biospecimens that will serve as a basis for future studies aimed at developing tools and biomarkers for progression and prognosis, identifying clinically relevant phenotypic characteristics, and establishing clearly defined endpoints for interventional studies.

PI Dr Elizabeth Coulthard

Local Ref: 3553