Orthopaedics - Current Research

The Bristol University Musculoskeletal research team are based at North Bristol NHS Trust.  This partnership enables clinicians and researchers to closely collaborate both locally and internationally to deliver high quality research based on our multidisciplinary expertise. The Avon Orthopaedic Centre has a long history of being one of the leading centres in the country for research and innovation in orthopaedic care.

Current studies:


This study aims to compare two different plates currently used in knee realignment surgery (high tibial osteotomy). The purpose of the metal plates is to maintain the correct realignment achieved at surgery whilst the bone heals. The two plates, TomoFix and ActivMotion are both used in current practice and comply safety regulations.

Once the knee correction has healed (approx. 12 months) the plate can be left in. Some patients may however experience discomfort that related to the plate and benefit from plate removal ,  about a year after their initial operation. The ActivMotion plate design is a smaller than the Tomofix and it is therefore potentially less likely to cause discomfort . It is anticipated that second operations for plate removal will be less frequent than for the Tomofix plate.

In this study we would like to compare the number of plates that need removal following surgery, assess pain levels in patients in the first two years following surgery and compare the amount of pain relief used in the immediate post-operative recovery period.

Participants will be asked to complete a questionnaire before they have their operation and twelve months after the operation to assess their pain and function. This information will be used to compare the outcome of the plates.

Host Site: North Bristol NHS Trust

Chief Investigator: Mr James Murray

End Date: 02/01/2021

Hip Replacement Failure and Bone Density Study

Hip replacements are a very common operation for people with painful arthritis. However, sometimes these hip replacements need to be done again because of pain and loosening.  We think that similar things may lead to loss of bone density (thinning of the bones) and loosening of joint replacements.  Because of this there is concern that loss of bone density may increase the need for further surgery to correct the loose joint replacement.

The study aims to see if there are differences in bone density and other factors that may explain why some people need their hip replacements done again (revised) and some do not.

Host Site: North Bristol NHS Trust

Chief Investigator: Dr Emma Clark

End Date: 31/12/2025